Hyperspectral wide-field time domain single-pixel diffuse optical tomography platform

Hyperspectral Imaging for Diffuse Optical Tomography

Diffuse optical tomography (DOT) has emerged in the last decade as a new and exciting tool for functional medical imaging with applications in a range of areas including breast cancer detection and diagnosis. DOT employs observations of near infrared (NIR) light that has propagated through tissue to reconstruct the spatial distribution of various chromophores present in the region of interest. ...

Hyperspectral image reconstruction for diffuse optical tomography

We explore the development and performance of algorithms for hyperspectral diffuse optical tomography (DOT) for which data from hundreds of wavelengths are collected and used to determine the concentration distribution of chromophores in the medium under investigation. An efficient method is detailed for forming the images using iterative algorithms applied to a linearized Born approximation mo...

Fast Algorithms for Hyperspectral Diffuse Optical Tomography

A Small Animal Time-resolved Optical Tomography Platform Using Wide-field Excitation

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Domain decomposition method for diffuse optical tomography

Diffuse optical tomography is modelled as an optimization problem to find the absorption and scattering coefficients that minimize the error between the measured photon density function and the approximated one computed using the coefficients. The problem is composed of two steps: the forward solver to compute the photon density function and its Jacobian (with respect to the coefficients), and ...